sigma receptor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12910	Sigma-1 receptor antagonist 1		Sigma receptor
	Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studie...		Sigma receptor
T12911	Sigma-1 receptor antagonist 2		Sigma receptor
	Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).		Sigma receptor
T12912	Sigma-1 receptor antagonist 3		Sigma receptor , HER
	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.		Sigma receptor , HER
T16883	Sigma-2 receptor antagonist 1		Others
	Sigma-2 receptor antagonist 1 is an antagonist of the sigma-2 (σ-2) receptor.		Others
T4596	4-IBP		Sigma receptor
	4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .		Sigma receptor
T9244	σ1 Receptor antagonist-1		Sigma receptor
	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.		Sigma receptor
T7488	BD1063 dhydrochloride	BD1063	Sigma receptor
	BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).		Sigma receptor
T78734	Sigma-1 receptor antagonist 5		Sigma receptor
	Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptors (Ki=4.5 nM (σ1R), 10 nM (σ2R)) and the histamine H3 receptor...		Sigma receptor
T5027	Dimemorfan phosphate	3,17-dimethylmorphinan	Sigma receptor
	Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.		Sigma receptor
T1180	Blonanserin	AD-5423	Dopamine Receptor , Sigma receptor , 5-HT Receptor , Adrenergic Receptor
	Blonanserin (AD-5423) is an atypical antipsychotic approved in Japan in January, 2008. Relative to many other antipsychotics, blonanserin has an improved tolerability profile, lacking side effects such as extrapyramidal ...
T15393	Glycerol phenylbutyrate	HPN-100	Sigma receptor
	Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).		Sigma receptor
T7780	Blarcamesine	AE-37,AVex-73	AChR
	Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.		AChR
T1740	BD-1047 dihydrobromide	BD1047.2HBr	Sigma receptor
	BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy in schizophrenia.		Sigma receptor
T15034	Roluperidone	CYR-101,MIN-101,MT-210	Sigma receptor , 5-HT Receptor
	Roluperidone (CYR-101) is a novel cyclic amide derivative. It has high equipotent affinities for 5-HT2A and σ2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and σ2).		Sigma receptor , 5-HT Receptor
T8834	EST64454 hydrochloride	EST64454	Sigma receptor
	EST64454 hydrochloride (EST64454) is a highly soluble σ1 receptor antagonist (Ki : 22 nM),has the potential for Pain Management.		Sigma receptor
T5969	Ditolylguanidine	DTG,Di-o-tolylguanidine,1,3-Di-o-tolylguanidine	Sigma receptor
	Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).		Sigma receptor
T1885	Siramesine hydrochloride	Lu 28-179 hydrochloride	Ferroptosis , Sigma receptor , lysosomal autophagy
	Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.		Ferroptosis , Sigma receptor , lysosomal autophagy
T4111	Blarcamesine hydrochloride	Anavex 2-73,AVex-73 hydrochloride,AE-37 hydrochloride	Sigma receptor
	Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).		Sigma receptor
T3198L	PRE-084 hydrochloride		Sigma receptor
	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).		Sigma receptor
T1865	S1RA	E-52862	Sigma receptor
	S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2 receptor (σ2R, Ki > 1000 nM).		Sigma receptor